50L all glass jacketed vessels are used at Onyx for scale up. Heating and cooling are provided by Huber oil circulators maintained in plant rooms behind the fume cupboards. The units are fully programmable and provide jacket temperatures of -30°C to 200°C without a change of oil. The all glass construction is ideal for the early development and initial scale up batches as the reactions can be easily observed to ensure the chemistry performs as well as the smaller scale jacketed vessels. Approximately 1-5kg of material is isolated per batch.